Here is a breakdown for some handpaint style material done with Substance Designer 2020.1.2
This breakdown will help you to understand a way to create some Handpaint/Ghibli textures with Substance Designer.
It is not a full PBR process, but with it, and by adjusting some node, you can achieve it easly.
In this Breakdown, you will have :
1h17 of a breakdown video
Documentation about the Breakdown
Sbs files with two textures graph fully documented